Renal Digest
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    Immunotactoid glomerulopathy


Differential diagnosis:
Fibrillary glomerulonephritis
Immunoglobulin A (IgA) nephropathy, mesangioproliferative type
Membranoproliferative glomerulonephritis (MPGN), idiopathic, type I
Cryoglobulin-associated glomerulonephritis
Lupus nephritis, focal (class III)

Immunofluorescence:   

      Monoclonal (kappa or lambda) reactivity of immunoglobulins (usually IgG)
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Immunotactoid glomerulopathy: subepithelial microtubular deposits, with parallel arrangement; EM, 38,000x
Subepithelial, parallely arranged microtubular deposits; EM, 14,000x
Subepithelial deposits of various sizes, without basement membrane `spikes`, in immunotactoid glomerulopathy; EM, 8,900x
Substructural organization of deposits in immunotactoid glomerulopathy; EM, 28,000x
Mesangial microtubular deposits in immunotactoid glomerulopathy; EM, 18,000x
Very thickened capillary loop due to a presence of organized intramembranous deposits, in a case of immunotactoid glomerulopathy; EM, 8,000x
Peculiar subepithelial deposit with curvilinear and stright shape of long fibrils; EM, 30,000x
Subepithelial and intramembranous organized deposits in immunotactoid glomerulopathy. Note complete effacement of visceral epithelial cell foot processes; EM, 15,000x
Organized mesangial deposits in a patient with circulating IgG-kappa paraprotein and lymphoproliferative disorder; EM, 25,000x
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